An Evolving Role for Notch Signaling in Heart Regeneration of the Zebrafish Danio rerio

Zebrafish cardiac tissue may regenerate post-ventricular amputation via the Notch pathway. Notch is important in cellular differentiation and proliferation of cardiomyocytes. Damage results in altered hemodynamics, and the mechanosensitive ion channel Trpv4 may interact with cardiac cilia to induce the Notch pathway via Klf2. Notch stimulates downstream Erbb2 and BMP signaling, perhaps offering a molecular mechanism by which Notch-mediated cardiac regeneration may occur in the zebrafish.