This study examines the impact of digital transformation on organizational change and employee adaptability in the context of firms in the United Arab Emirates (UAE). Based on a primary quantitative survey of 201 mid-level employees, the research explores how digital innovation reshapes business processes, organizational culture, and workforce dynamics. It emphasizes the importance of effective change management strategies, leadership support, and structured training programs in ensuring smooth digital transitions. The findings confirm that digital transformation significantly influences organizational culture by driving structural changes, improving workflows, and enhancing decision-making processes. Regression analysis revealed that digital transformation accounts for 86.6% of the variance in organizational change and 86.2% in employee adaptability. Furthermore, communication effectiveness and workflow integration emerged as the strongest indirect predictors of adaptability. Employee adaptability emerges as a critical factor for successful digital transformation, with training opportunities and leadership guidance serving as key enablers. The study contributes to academic literature by linking digital transformation with established theories of organizational change and employee adaptability. It also provides practical recommendations for managers and policymakers to foster a culture of continuous learning, strengthen employee readiness, and align organizational practices with digital strategies to achieve long-term success.