This paper seeks to analyze the impact of Science, Technology and Innovation (STI) clubs, on performance of secondary school students. The study focuses on Mwanza Secondary School. The study will look at the experiences, challenges and success stories of the school. The year 2018 saw the introduction of STI Clubs in most secondary schools of Malawi including Mwanza Secondary School. These clubs were spear headed by Dr. Chomora Mikeka who is currently the Director of the Department of Science, Technology and Innovation. The Department now works with the Department of Innovation and creativity in the office of the president and cabinet, which was established in November 2020 by His Excellency, Dr. Lazarous MCathy Chakwera, The President of the Republic of Malawi. Through these initiatives, Mwanza secondary school’s performance, especially in science subjects improved and more students are currently being selected to public universities. The club helps equip all science students with the necessary skills and knowledge to solve various problems in their community through innovation and creativity. These innovations are fostering the achievement of the pillars of Malawi 2063 and the Malawi Recovery Plan. Since 2018, the club has participated in four National School Sciences Fair hosted by Kamuzu Academy. Currently, on October 2023, Mwanza secondary school registered one of its innovations, “Antifungal lotion”, with the Innovation and Engineering Hub of the Malawi University of Science and Technology (MUST-MIIRI).