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Preprint
Open Review
20 Sep 2022
| By
Manuel Manuel Rayo Quesada

Behavioral economics is a fairly new field within science economics, which attempts to explain human behavior from the point of view of social preferences and heuristics. He bases his study on the processes of taking of decision by an individual, but unlike the model of homo oeconomicus (an expression formulated by John Stuart...

Preprint
Open Review
20 Sep 2022
| By
Manuel Manuel Rayo Quesada

In the analysis of financial time series, the Autoregressive models with Conditional Heteroskedasticity (ARCH) and their generalization, the GARCH models, have been widely used, demonstrating their good qualities for modeling the volatilities typical of this type of series. As an alternative, Switching Markov models have emerged that allow the inclusion of random phenomena as...

Preprint
Open Review
9 Sep 2022
| By
Christopher Christopher Teske

Current research suggests that MDMA, or 3,4-methylenedioxymethamphetamine, may be particularly useful in the treatment of post-traumatic stress disorder (PTSD). Belonging to a class of substances known as entactogens, MDMA and its derivatives bear structural motifs common to both psychedelics and amphetamines, giving them a unique pharmacology with distinct subjective effects....

Preprint
Open Review
2 Sep 2022
| By
Lucía Guadalupe Lucía Guadalupe Reynosa Gómez

El constructo teórico “Curriculo” es uno esos constructos o categorías en educación sobre las que se ha escrito una inmensa cantidad de libros, artículos, ponencias, reseñas y todas las formas de expresión oral y escrita, impresa o electrónica que podamos imaginar y en una gran diversidad de espacios geográfico-culturales. Entonces, si deseamos tener una...

Preprint
Open Review
30 Aug 2022
| By
Christopher Christopher Teske

Zebrafish cardiac tissue may regenerate post-ventricular amputation via the Notch pathway. Notch is important in cellular differentiation and proliferation of cardiomyocytes. Damage results in altered hemodynamics, and the mechanosensitive ion channel Trpv4 may interact with cardiac cilia to induce the Notch pathway via Klf2. Notch stimulates downstream Erbb2 and BMP...

Preprint
Open Review
30 Aug 2022
| By
Christopher Christopher Teske

As science unravels ketamine’s mechanisms of action to better understand its efficacy as an antidepressant, its antibacterial activity has been probed at the same time. Current research has found a naturally-occurring, fungal origin for the drug, exhibiting antiparasitic properties. The current onslaught of research into ketamine’s therapeutic potential has led...

Preprint
Open Review
30 Aug 2022
| By
Christopher Christopher Teske

As ketamine’s demonstrable therapeutic applications have become ever more popular, earlier research lauding its potential as an antimicrobial and antiparasitic agent has quietly reemerged. The last several years have seen a palpable enthusiasm regarding ketamine’s potential utility in the treatment of depression, anxiety, and related maladies. This research culminates at...

Preprint
Open Review
30 Aug 2022
| By
Christopher Christopher Teske

Despite differing pharmacodynamics, ketamine and serotonergic psychedelics may share downstream effects crucial to their rapid and sustained antidepressant activity. Both ketamine and serotonergic psychedelics (SPs) have been studied as novel treatments for depression, particularly Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD). Promising results and demonstrated benefits in preliminary research...

Preprint
Open Review
30 Aug 2022
| By
Christopher Christopher Teske

Even at therapeutic doses, ibogaine may cause potentially life-threatening cardiac arrhythmia. Science is beginning to unravel the pharmacological factors that may underlie ibogaine-induced cardiotoxicity.-Ibogaine has shown promising anti-addictive effects in both animal models and human trials, aiding those in search of a novel treatment for addiction and the compulsive behaviors...

Preprint
Open Review
20 Aug 2022
| By
Liesbeth Liesbeth van Heel,
Clarine Clarine Van Oel

The design of a new hospital is typically used as a catalyst for change, redesign and implementation of new work processes to improve health services. Perceived outcomes after relocation may be linked to the success of co-design and stakeholder engagement processes. Especially in striking the right balance between the building...

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